Irritant the disaster area

The multi-disciplinary study of histopathology and toxicology of Bhopal gas tragedy resolved several issues. First, the progression of severe pulmonary oedema to chronic fibrosis was confirmed experimentally, following a single exposure to MIC. Analysis of the residue in Tank 610 revealed over 21 chemicals. Apart from MIC and HCN, some of them were tracked down to the blood and viscera of dead and living exposees. The rationale of NaTS therapy was substantiated by elevated urinary NaSCN levels in Double Blind Clinical Trials as well as patients. Apart from cyanide, the ‘cherry red’ discolouration was also shown to result from binding of MIC to end-terminal valine residues of Hb, as shown by changes in 2-3DPG levels and blood gas profiles. The finding of Ncarbamoylation of several other end-terminal amino acid s of tissue proteins confirmed the distribution of MIC within the body, although the underlying mechanism is not yet fully understood. Possibly, the much faster S-carbamoylated compounds of the blood like glutathione and other sulphydrylcontaining enzymes like rhodanese could be responsible for re-circulation of MIC and protracted cyanide toxicity. It is hoped that eventually the enigma of the Bio-chemical Lesion of MIC toxicity will be unraveled ( Sriramachari, 2004 ).

plague 1382, "affliction, calamity, evil, scourge," also "malignant disease," from . plague, from . plaga, used in Vulgate for "pestilence," from L. plaga "stroke, wound," probably from root of plangere "to strike, lament (by beating the breast)," from or cognate with Gk. (Doric) plaga "blow," from PIE *plag- "hit" (cf. flocan "to strike, beat," Goth. flokan "to bewail," Ger. fluchen, . floka "to curse"). plag (gen. plaige) "plague, pestilence" is from L. Specifically in ref. to "bubonic plague" from 1601. The verb is from 1481; in the sense of "bother, annoy" it is first ... recorded 1594. Plaguey "vexatious" is attested from 1615.

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